What makes plaque rupture




















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Leung D. Y Glagov S Mathews M. B Cyclic stretching stimulates synthesis of matrix components by arterial smooth muscle cells in vitro Science Cyclic strain and vascular cell biology. In: Sumpio BE, editor. Hemodynamic forces and vascular cell biology. Banes A. J Tauzaki M Yamamoto J et al.

Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals Biochem Cell Biol 73 Davies P. F Barbee K. A Volin M. V et al. Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction Annu Rev Physiol 59 A Berk B. C Mechanotransduction in endothelial cells: temporal signaling events in response to shear stress J Vasc Res 34 Cholesterol and other fatty substances also circulate in the blood.

Over time, these substances can be deposited in the artery walls, a condition called atherosclerosis. The deposited cholesterol, or plaque, can build up over time, causing hardening and narrowing of the otherwise smooth artery walls.

The dynamic interplay between the actual plaque vulnerability and external stresses "triggers" probably determines the particular moment and point of rupture, if this occurs. A prerequisite is the presence of a vulnerable plaque. August 5, David Dichek. Image of a histology slide showing arterial plaque rupture and blood clot accumulation. Latest posts November 10, November 5, Getting through winter without feeling SAD. November 4, AI software created to help psychotherapists enhance skills.



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